Lipids play a more significant role in Parkinson's disease and its related brain disorders than
is currently recognized, supporting a “lipid cascade”. The 14 kDa protein α-synuclein (αS) is …

Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian
cells. PE comprises about 15–25% of the total lipid in mammalian cells; it is enriched in the …

Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Microglia, once viewed as static bystanders with limited homeostatic functions, are now
considered key players in the development of neuroinflammatory and neurodegenerative …

Lipid rafts are cholesterol-and sphingomyelin-enriched microdomains that provide a highly
saturated and viscous physico-chemical microenvironment to promote protein-lipid and …

Reactive oxygen species (ROS) are produced at low levels in mammalian cells by various
metabolic processes, such as oxidative phosphorylation by the mitochondrial respiratory …

Neurodegenerative disorders are among the most studied issues both in medicine and
pharmacy. Despite long and extensive research, there is no effective treatment prescribed …

The distribution and tempo of neuronal loss in Parkinson's disease correlates poorly with the
characteristic and more widely spread intracellular changes associated with the disease …

Lipid droplets (LDs) were considered as a mere lipid storage organelle for a long time.
Recent evidence suggests that LDs are in fact distinct and dynamic organelles with a …

Parkinson disease (PD) is the second most common neurodegenerative disease after
Alzheimer disease. Although PD has a relatively narrow clinical phenotype, it has become …