The complex cross‐talk of intricate intercellular signaling networks between the tumor and
stromal cells promotes cancer progression. Hypoxia is one of the most common conditions …

Nanomaterials have been extensively used for cancer therapy and diagnosis due to their
designability, multifunctionality, and unique in vivo distribution. Metal ions are increasingly …

Adaptation of cancer cells to their microenvironment is an important driving force in the
clonal selection that leads to invasive and metastatic disease. O 2 concentrations are …

Abstract Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are
involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose …

Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and …

Solid tumours contain regions at very low oxygen concentrations (hypoxia), often
surrounding areas of necrosis. The cells in these hypoxic regions are resistant to both …

The regulation of angiogenesis by hypoxia is an important component of homeostatic
mechanisms that link vascular oxygen supply to metabolic demand. Molecular …

During the past century it has been established that regions within solid tumours experience
mild to severe O2 deprivation owing to aberrant vascular function. These hypoxic regions …

There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …

Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …