Kinesin superfamily motor proteins and intracellular transport

N Hirokawa, Y Noda, Y Tanaka, S Niwa - Nature reviews Molecular cell …, 2009 - nature.com
Intracellular transport is fundamental for cellular function, survival and morphogenesis.
Kinesin superfamily proteins (also known as KIFs) are important molecular motors that …

Analysis of the kinesin superfamily: insights into structure and function

H Miki, Y Okada, N Hirokawa - Trends in cell biology, 2005 - cell.com
Kinesin superfamily proteins (KIFs) are key players or 'hub'proteins in the intracellular
transport system, which is essential for cellular function and morphology. The KIF …

Molecular motors and mechanisms of directional transport in neurons

N Hirokawa, R Takemura - Nature Reviews Neuroscience, 2005 - nature.com
Intracellular transport is fundamental for neuronal morphogenesis, function and survival.
Many proteins are selectively transported to either axons or dendrites. In addition, some …

Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics

N Hirokawa, Y Noda - Physiological reviews, 2008 - journals.physiology.org
Various molecular cell biology and molecular genetic approaches have indicated significant
roles for kinesin superfamily proteins (KIFs) in intracellular transport and have shown that …

Integrated regulation of motor-driven organelle transport by scaffolding proteins

M Fu, ELF Holzbaur - Trends in cell biology, 2014 - cell.com
Intracellular trafficking pathways, including endocytosis, autophagy, and secretion, rely on
directed organelle transport driven by the opposing microtubule motor proteins kinesin and …

Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

KJ Verhey, D Meyer, R Deehan, J Blenis… - The Journal of cell …, 2001 - rupress.org
The cargo that the molecular motor kinesin moves along microtubules has been elusive. We
searched for binding partners of the COOH terminus of kinesin light chain, which contains …

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

A Kamal, GB Stokin, Z Yang, CH Xia, LSB Goldstein - Neuron, 2000 - cell.com
We analyzed the mechanism of axonal transport of the amyloid precursor protein (APP),
which plays a major role in the development of Alzheimer's disease. Coimmunoprecipitation …

Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain

DS Friedman, RD Vale - Nature cell biology, 1999 - nature.com
Conventional kinesin transports membranes along microtubules in vivo, but the majority of
cellular kinesin is unattached to cargo. The motility of non-cargo-bound, soluble kinesin may …

Kinesin superfamily: roles in breast cancer, patient prognosis and therapeutics

AJ Lucanus, GW Yip - Oncogene, 2018 - nature.com
Breast cancer pathobiology is known to be influenced by the differential expression of a
group of proteins called the kinesin superfamily (KIFs), which is instrumental in the …

p120 catenin associates with kinesin and facilitates the transport of cadherin–catenin complexes to intercellular junctions

X Chen, S Kojima, GG Borisy, KJ Green - The Journal of cell biology, 2003 - rupress.org
p120 catenin (p120) is a component of adherens junctions and has been implicated in
regulating cadherin-based cell adhesion as well as the activity of Rho small GTPases, but its …