Pathogenic animal trypanosomes affecting livestock have represented a major constraint to
agricultural development in Africa for centuries, and their negative economic impact is …

African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense,
and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and …

Sexual reproduction and clonality in eukaryotes are mostly seen as exclusive, the latter
being rather exceptional. This view might be biased by focusing almost exclusively on …

The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging
across many parts of Africa. Resistance to existing drugs was emerging, and many programs …

Human African Trypanosomiasis (HAT, sleeping sickness) and Animal African
Trypanosomiasis (AAT) are neglected tropical diseases generally caused by the same …

Since their endosymbiotic origin, mitochondria have lost most of their genes. Although many
selective mechanisms underlying the evolution of mitochondrial genomes have been …

The long slender bloodstream form Trypanosoma brucei maintains its essential
mitochondrial membrane potential (ΔΨm) through the proton-pumping activity of the FoF1 …

Eukaryotic cells can survive the loss of their mitochondrial genome, but consequently suffer
from severe growth defects.'Petite yeasts', characterized by mitochondrial genome loss, are …

African trypanosomes are responsible for important diseases of humans and animals in sub-
Saharan Africa. The best-studied species is Trypanosoma brucei, which is characterized by …

Two key biological features distinguish Trypanosoma evansi from the T. brucei group:
independence from the tsetse fly as obligatory vector, and independence from the need for …