Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …

As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides
both physical support and signaling regulation to cells. Some ECM molecules provide a …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

INTRODUCTION Vertebrate development comprises multiple complex morphogenetic
processes that shape the embryonic body plan through self-organization of pluripotent stem …

Mammalian embryos sequentially differentiate into trophectoderm and an inner cell mass,
the latter of which differentiates into primitive endoderm and epiblast. Trophoblast stem (TS) …

Embryogenesis is directed by morphogens that induce differentiation within a defined tissue
geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) …

Organoids are lumen‐containing multicellular structures that recapitulate key features of the
organs, and are increasingly used in models of disease, drug testing, and regenerative …

Gene regulatory networks and tissue morphogenetic events drive the emergence of shape
and function: the pillars of embryo development. Although model systems offer a window …

The development of an organism depends on intrinsic genetic programs of progenitor cells
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …