What made sesquiterpene lactones reach cancer clinical trials?
A Ghantous, H Gali-Muhtasib, H Vuorela, NA Saliba… - Drug discovery today, 2010 - Elsevier
Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional
medicine against inflammation and cancer. This review focuses on the chemical and …
medicine against inflammation and cancer. This review focuses on the chemical and …
Assessment of herbal medicinal products: challenges, and opportunities to increase the knowledge base for safety assessment
SA Jordan, DG Cunningham, RJ Marles - Toxicology and applied …, 2010 - Elsevier
Although herbal medicinal products (HMP) have been perceived by the public as relatively
low risk, there has been more recognition of the potential risks associated with this type of …
low risk, there has been more recognition of the potential risks associated with this type of …
Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities
VB Mathema, YS Koh, BC Thakuri, M Sillanpää - Inflammation, 2012 - Springer
Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum
parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a …
parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a …
Quantitative structure− activity relationship of sesquiterpene lactones as inhibitors of the transcription Factor NF-κB
B Siedle, AJ García-Piñeres, R Murillo… - Journal of medicinal …, 2004 - ACS Publications
Sesquiterpene lactones (SLs) are the active compounds of a variety of tradionally used
medicinal plants from the Asteraceae family. They are known to possess a considerable …
medicinal plants from the Asteraceae family. They are known to possess a considerable …
Fungicidal activity of natural and synthetic sesquiterpene lactone analogs
DE Wedge, JCG Galindo, FA Macıas - Phytochemistry, 2000 - Elsevier
Fungicidal activity of 36 natural and synthetic sesquiterpene lactones with guaianolide,
trans, trans-germacranolide, cis, cis-germacranolide, melampolide, and eudesmanolide …
trans, trans-germacranolide, cis, cis-germacranolide, melampolide, and eudesmanolide …
Use of fingerprinting and marker compounds for identification and standardization of botanical drugs: strategies for applying pharmaceutical HPLC analysis to herbal …
NJ Lazarowych, P Pekos - Drug information journal: DIJ/Drug Information …, 1998 - Springer
For standardization of natural product drugs, single chemical entities,“marker
compounds,“may be used as potency standards in high performance liquid chromatography …
compounds,“may be used as potency standards in high performance liquid chromatography …
Sesquiterpene lactones: More than protective plant compounds with high toxicity
GF Padilla-Gonzalez, FA dos Santos… - Critical Reviews in …, 2016 - Taylor & Francis
Sesquiterpene lactones (STLs) constitute a large group of secondary metabolites that are
widely distributed in several angiosperm plant families and a few bryophytes, including …
widely distributed in several angiosperm plant families and a few bryophytes, including …
[HTML][HTML] Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis
D Carlisi, G Buttitta, R Di Fiore, C Scerri… - Cell death & …, 2016 - nature.com
Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma
associated with a high rate of recidivism. In this paper, we report the production of …
associated with a high rate of recidivism. In this paper, we report the production of …
[图书][B] Herbal medicines in pregnancy and lactation: an evidence-based approach
Exposures to over-the-counter products are frequent in pregnant women. Perhaps this is a
paradoxical response to the decreased use of prescribed medications during pregnancy for …
paradoxical response to the decreased use of prescribed medications during pregnancy for …
Effect of sesquiterpene lactones on antioxidant enzymes and some drug-metabolizing enzymes in rat liver and kidney
J Jodynis-Liebert, M Murias, E Boszyk - Planta medica, 2000 - thieme-connect.com
Previously we have reported that several sesquiterpene lactones isolated from Helenium
aromaticum and Telekia speciosa showed pro-oxidative properties and caused glutathione …
aromaticum and Telekia speciosa showed pro-oxidative properties and caused glutathione …