FGFs, heparan sulfate and FGFRs: complex interactions essential for development

DM Ornitz - Bioessays, 2000 - Wiley Online Library
Fibroblast growth factors (FGFs) comprise a large family of developmental and physiological
signaling molecules. All FGFs have a high affinity for the glycosaminoglycan heparin and for …

The roles of FGFs in the early development of vertebrate limbs

GR Martin - Genes & development, 1998 - genesdev.cshlp.org
''Fibroblast growth factor''(FGF) was first identified 25 years ago as a mitogenic activity in
pituitary extracts (Armelin 1973; Gospodarowicz 1974). This modest observation …

[HTML][HTML] Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs

FA Ramírez-Weber, TB Kornberg - Cell, 1999 - cell.com
Wing imaginal disc cells in Drosophila develop by using information received from a
signaling center associated with the anterior/posterior compartment border. We show here …

Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor …

J Wu, Y Shao, X Hua, Y Wang, D Wang - Chemosphere, 2024 - Elsevier
Nanoplastics at environmentally relevant concentrations (ERCs) could cause
transgenerational toxicity on organisms. Caenorhabditis elegans is an important model for …

Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis

M Weaver, NR Dunn, BLM Hogan - Development, 2000 - journals.biologists.com
Morphogenesis of the mouse lung involves reciprocal interactions between the epithelial
endoderm and the surrounding mesenchyme, leading to an invariant early pattern of …

A real-time biosensor for ERK activity reveals signaling dynamics during C. elegans cell fate specification

C De la Cova, R Townley, S Regot, I Greenwald - Developmental cell, 2017 - cell.com
Kinase translocation reporters (KTRs) are genetically encoded fluorescent activity sensors
that convert kinase activity into a nucleocytoplasmic shuttling equilibrium for visualizing …

[HTML][HTML] The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans

K Shen, CI Bargmann - Cell, 2003 - cell.com
During nervous system development, neurons form reproducible synapses onto specific
targets. Here, we analyze the development of stereotyped synapses of the C. elegans HSNL …

Crosstalk Between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development

AS Yoo, C Bais, I Greenwald - Science, 2004 - science.org
The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in
animal development. The fates of six vulval precursor cells are patterned through the action …

[HTML][HTML] Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1

K Shen, RD Fetter, CI Bargmann - Cell, 2004 - cell.com
Synaptic connections in the nervous system are directed onto specific cellular and
subcellular targets. Synaptic guidepost cells in the C. elegans vulval epithelium drive …

Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans

Y Hong, R Roy, V Ambros - Development, 1998 - journals.biologists.com
ABSTRACT C. elegans cki-1 encodes a member of the CIP/KIP family of cyclin-dependent
kinase inhibitors, and functions to link postembryonic developmental programs to cell cycle …