A spotlight on the diagnostic methods of a fatal disease Visceral Leishmaniasis

A Kumar, SC Pandey, M Samant - Parasite immunology, 2020 - Wiley Online Library
Leishmania donovani (a causative agent of visceral leishmaniasis) poses a serious health
threat to the human population which is fatal if left untreated. The life cycle of Leishmania …

Intravacuolar pathogens hijack host extracellular vesicle biogenesis to secrete virulence factors

A Gioseffi, MJ Edelmann, PE Kima - Frontiers in Immunology, 2021 - frontiersin.org
Extracellular vesicles (EVs) have garnered significant interest in recent years due to their
contributions to cell-to-cell communication and disease processes. EVs are composed of a …

Leishmania-infected macrophages release extracellular vesicles that can promote lesion development

A Gioseffi, T Hamerly, K Van, N Zhang… - Life science …, 2020 - life-science-alliance.org
Leishmania donovani infection of macrophages results in quantitative and qualitative
changes in the protein profile of extracellular vesicles (EVs) released by the infected host …

Characterization and proteomic analysis of plasma EVs recovered from healthy and diseased dogs with canine leishmaniosis

S Esteves, C Lima, I Costa, H Osório… - International Journal of …, 2023 - mdpi.com
Dogs are highly valued companions and work animals that are susceptible to many life-
threatening conditions such as canine leishmaniosis (CanL). Plasma-derived extracellular …

Circulating immune complexes levels correlate with the progression of canine leishmaniosis in naturally infected dogs

N Parody, C Cacheiro-Llaguno, C Osuna… - Veterinary …, 2019 - Elsevier
Dogs are the main domestic reservoir of Leishmania infantum, and in cases of uncontrolled
infection, a strong humoral immune response is elicited, which is inefficient against the …

Amphotericin B nano-assemblies circumvent intrinsic toxicity and ensure superior protection in experimental visceral leishmaniasis with feeble toxic manifestation

F Jamal, I Altaf, G Ahmed, S Asad, H Ahmad, Q Zia… - Vaccines, 2023 - mdpi.com
In spite of its high effectiveness in the treatment of both leishmaniasis as well as a range of
fungal infections, the free form of the polyene antibiotic amphotericin B (AmB) does not …

Rapid Determination of Vitamin D3 in Aquatic Products by Polypyrrole-Coated Magnetic Nanoparticles Extraction Coupled with High-Performance Liquid …

X Liu, R Song, R Wei - Nanomaterials, 2022 - mdpi.com
A method using polypyrrole-coated Fe3O4 (Fe3O4@ PPy composites) based extraction
coupled with high performance liquid chromatography was developed for adsorption and …

Screening diagnostic candidates from Leishmania infantum proteins for human visceral leishmaniasis using an immunoproteomics approach

DP Lage, F Ludolf, PC Silveira, AS Machado… - Parasitology, 2019 - cambridge.org
There is no suitable vaccine against human visceral leishmaniasis (VL) and available drugs
are toxic and/or present high cost. In this context, diagnostic tools should be improved for …

A link between circulating immune complexes and acute kidney injury in human visceral leishmaniasis

G Corrêa-Castro, ML Silva-Freitas, L de Paula… - Scientific Reports, 2024 - nature.com
Visceral leishmaniasis (VL) is an infectious disease caused by Leishmania infantum.
Clinically, VL evolves with systemic impairment, immunosuppression and hyperactivation …

Leishmaniasis: Current Trends in Microbiology and Pharmacology

I Adams, AA Kwapong, E Boafo, E Twum… - Rising Contagious …, 2024 - Wiley Online Library
Leishmaniasis is a neglected tropical disease infecting the world's poorest populations in
over 90 countries throughout Asia, Africa, the Middle East, and Central and South America …