Nanomedicine (s) under the microscope
R Duncan, R Gaspar - Molecular pharmaceutics, 2011 - ACS Publications
Depending on the context, nanotechnologies developed as nanomedicines (nanosized
therapeutics and imaging agents) are presented as either a remarkable technological …
therapeutics and imaging agents) are presented as either a remarkable technological …
Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics
Synthetic methods in polymer chemistry have evolved tremendously during the last decade.
Nowadays more and more attention is devoted to the application of those tools in the …
Nowadays more and more attention is devoted to the application of those tools in the …
Endocytosis and intracellular trafficking as gateways for nanomedicine delivery: opportunities and challenges
R Duncan, SCW Richardson - Molecular pharmaceutics, 2012 - ACS Publications
More than 40 nanomedicines are already in routine clinical use with a growing number
following in preclinical and clinical development. The therapeutic objectives are often …
following in preclinical and clinical development. The therapeutic objectives are often …
Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics
R Gaspar, R Duncan - Advanced drug delivery reviews, 2009 - Elsevier
Since the early 1990s polymer–protein conjugates (included PEGylated enzymes and
cytokines), polymeric drugs and polymeric sequestrants have been entering the market as …
cytokines), polymeric drugs and polymeric sequestrants have been entering the market as …
On the cellular processing of non-viral nanomedicines for nucleic acid delivery: mechanisms and methods
D Vercauteren, J Rejman, TF Martens… - Journal of controlled …, 2012 - Elsevier
In the field of nanomedicine, ample attention has been paid to the development of
nanocarriers for the intracellular delivery of therapeutic cargo, such as nucleic acids for gene …
nanocarriers for the intracellular delivery of therapeutic cargo, such as nucleic acids for gene …
Application of advances in endocytosis and membrane trafficking to drug delivery
Multidisciplinary research efforts in the field of drug delivery have led to the development of
a variety of drug delivery systems (DDS) designed for site-specific delivery of diagnostic and …
a variety of drug delivery systems (DDS) designed for site-specific delivery of diagnostic and …
Peptide-based polymer therapeutics
A Duro-Castano, I Conejos-Sánchez, MJ Vicent - Polymers, 2014 - mdpi.com
Polypeptides are envisaged to achieve a major impact on a number of different relevant
areas such as biomedicine and biotechnology. Acquired knowledge and the increasing …
areas such as biomedicine and biotechnology. Acquired knowledge and the increasing …
Modulating angiogenesis with integrin-targeted nanomedicines
A Duro-Castano, E Gallon, C Decker… - Advanced Drug Delivery …, 2017 - Elsevier
Targeting angiogenesis-related pathologies, which include tumorigenesis and metastatic
processes, has become an attractive strategy for the development of efficient guided …
processes, has become an attractive strategy for the development of efficient guided …
Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses
CI Øie, DL Wolfson, T Yasunori, G Dumitriu… - Scientific Reports, 2020 - nature.com
The liver is constantly exposed to dietary antigens, viruses, and bacterial products with
inflammatory potential. For decades cellular uptake of virus has been studied in connection …
inflammatory potential. For decades cellular uptake of virus has been studied in connection …
Short ligands affect modes of QD uptake and elimination in human cells
NA Al-Hajaj, A Moquin, KD Neibert, GM Soliman… - Acs Nano, 2011 - ACS Publications
In order to better understand nanoparticle uptake and elimination mechanisms, we designed
a controlled set of small, highly fluorescent quantum dots (QDs) with nearly identical …
a controlled set of small, highly fluorescent quantum dots (QDs) with nearly identical …