Nanomedicine (s) under the microscope

R Duncan, R Gaspar - Molecular pharmaceutics, 2011 - ACS Publications
Depending on the context, nanotechnologies developed as nanomedicines (nanosized
therapeutics and imaging agents) are presented as either a remarkable technological …

Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

M Barz, R Luxenhofer, R Zentel, MJ Vicent - Polymer Chemistry, 2011 - pubs.rsc.org
Synthetic methods in polymer chemistry have evolved tremendously during the last decade.
Nowadays more and more attention is devoted to the application of those tools in the …

Endocytosis and intracellular trafficking as gateways for nanomedicine delivery: opportunities and challenges

R Duncan, SCW Richardson - Molecular pharmaceutics, 2012 - ACS Publications
More than 40 nanomedicines are already in routine clinical use with a growing number
following in preclinical and clinical development. The therapeutic objectives are often …

Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics

R Gaspar, R Duncan - Advanced drug delivery reviews, 2009 - Elsevier
Since the early 1990s polymer–protein conjugates (included PEGylated enzymes and
cytokines), polymeric drugs and polymeric sequestrants have been entering the market as …

On the cellular processing of non-viral nanomedicines for nucleic acid delivery: mechanisms and methods

D Vercauteren, J Rejman, TF Martens… - Journal of controlled …, 2012 - Elsevier
In the field of nanomedicine, ample attention has been paid to the development of
nanocarriers for the intracellular delivery of therapeutic cargo, such as nucleic acids for gene …

Application of advances in endocytosis and membrane trafficking to drug delivery

Y Ju, H Guo, M Edman, SF Hamm-Alvarez - Advanced drug delivery …, 2020 - Elsevier
Multidisciplinary research efforts in the field of drug delivery have led to the development of
a variety of drug delivery systems (DDS) designed for site-specific delivery of diagnostic and …

Peptide-based polymer therapeutics

A Duro-Castano, I Conejos-Sánchez, MJ Vicent - Polymers, 2014 - mdpi.com
Polypeptides are envisaged to achieve a major impact on a number of different relevant
areas such as biomedicine and biotechnology. Acquired knowledge and the increasing …

Modulating angiogenesis with integrin-targeted nanomedicines

A Duro-Castano, E Gallon, C Decker… - Advanced Drug Delivery …, 2017 - Elsevier
Targeting angiogenesis-related pathologies, which include tumorigenesis and metastatic
processes, has become an attractive strategy for the development of efficient guided …

Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses

CI Øie, DL Wolfson, T Yasunori, G Dumitriu… - Scientific Reports, 2020 - nature.com
The liver is constantly exposed to dietary antigens, viruses, and bacterial products with
inflammatory potential. For decades cellular uptake of virus has been studied in connection …

Short ligands affect modes of QD uptake and elimination in human cells

NA Al-Hajaj, A Moquin, KD Neibert, GM Soliman… - Acs Nano, 2011 - ACS Publications
In order to better understand nanoparticle uptake and elimination mechanisms, we designed
a controlled set of small, highly fluorescent quantum dots (QDs) with nearly identical …