Background The syndrome consisting of primary hypothyroidism, precocious puberty, and
massive ovarian cysts was termed Van Wyk and Grumbach syndrome in 1960. Little is …

The association in young females of long-standing primary hypothyroidism, isosexual
precocious pseudopuberty and multicystic enlarged ovaries was first described in 1960 by …

Abstract Background In 1960 Van Wyk and Grumbach described a syndrome of juvenile
hypothyroidism, precocious puberty and ovarian enlargement. These findings undergo …

Context Prolonged hypothyroidism in children commonly causes short stature with delayed
bone maturation, and delayed puberty. However, a paradoxical occurrence of peripheral …

Abstract Van Wyk-Grumbach Syndrome (VWGS) is a constellation of symptoms including
precocious puberty without adrenarche, delayed bone age, ovarian cysts, and …

Van Wyk–Grumbach syndrome (VWGS) refers to the development of peripheral precocious
puberty, long-standing hypothyroidism, and gonadal masses; when not diagnosed, an …

Agirl aged six years, nine months presented with vagi-nal bleeding, which included clots
about 3 cm in diameter. The bleeding had started six days previously, and the patient was …

We report a 12‐year‐old female presenting with an abdominal tumor. Diagnostic workup
revealed giant bilateral ovarian cysts, severe hypothyroidism as well as an elevation of CA …

Aim To investigate the different characteristics of girls with pituitary hyperplasia secondary to
primary hypothyroidism (PPH), with and without sexual precocity. Methods Pituitary …

We report a case of sex cord tumor with annular tubules featuring a giant multilocular cyst,
grossly similar to cystadenoma, in the ovary of an 8.5 year old girl. Estrogen-related …