Guidelines for experimental models of myocardial ischemia and infarction

ML Lindsey, R Bolli, JM Canty Jr… - American Journal …, 2018 - journals.physiology.org
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

Regulation of coronary blood flow during exercise

DJ Duncker, RJ Bache - Physiological reviews, 2008 - journals.physiology.org
Exercise is the most important physiological stimulus for increased myocardial oxygen
demand. The requirement of exercising muscle for increased blood flow necessitates an …

Case report: Transplantation of human induced pluripotent stem cell-derived cardiomyocyte patches for ischemic cardiomyopathy

S Miyagawa, S Kainuma, T Kawamura… - Frontiers in …, 2022 - frontiersin.org
Despite major therapeutic advances, heart failure, as a non-communicable disease, remains
a life-threatening disorder, with 26 million patients worldwide, causing more deaths than …

Hibernating myocardium

G Heusch - Physiological reviews, 1998 - journals.physiology.org
Heusch, Gerd. Hibernating Myocardium. Physiol. Rev. 78: 1055–1085, 1998.—Decreased
myocardial contraction occurs as a consequence of a reduction in blood flow. The concept of …

Myocardial hibernation: a delicate balance

G Heusch, R Schulz… - American Journal of …, 2005 - journals.physiology.org
The pathophysiology of myocardial hibernation is characterized as a situation of reduced
regional contractile function distal to a coronary artery stenosis that recovers after removal of …

The representative porcine model for human cardiovascular disease

Y Suzuki, AC Yeung, F Ikeno - BioMed Research International, 2011 - Wiley Online Library
To improve human health, scientific discoveries must be translated into practical
applications. Inherent in the development of these technologies is the role of preclinical …

Hibernating myocardium: chronically adapted to ischemia but vulnerable to sudden death

JM Canty Jr, G Suzuki, MD Banas, F Verheyen… - Circulation …, 2004 - Am Heart Assoc
The inability to reproduce spontaneous ventricular fibrillation in an animal model of chronic
coronary artery disease has limited advances in understanding mechanisms of sudden …

The in-situ pig heart with regional ischemia/reperfusion—ready for translation

G Heusch, A Skyschally, R Schulz - Journal of molecular and cellular …, 2011 - Elsevier
The pig heart in situ with regional myocardial ischemia and reperfusion is of unique
translational value. Cardiac size, heart rate and blood pressure are similar to those in …

Program of cell survival underlying human and experimental hibernating myocardium

C Depre, SJ Kim, AS John, Y Huang… - Circulation …, 2004 - Am Heart Assoc
Hibernating myocardium refers to chronically dysfunctional myocardium in patients with
coronary artery disease in which cardiac viability is maintained and whose function …

Translational physiology: porcine models of human coronary artery disease: implications for preclinical trials of therapeutic angiogenesis

GC Hughes, MJ Post, M Simons… - Journal of Applied …, 2003 - journals.physiology.org
“Therapeutic angiogenesis” describes an emerging field of cardiovascular medicine
whereby new blood vessels are induced to grow to supply oxygen and nutrients to ischemic …