Guidelines for experimental models of myocardial ischemia and infarction
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …
ischemia with or without reperfusion, and basic and translational research is needed to …
Regulation of coronary blood flow during exercise
DJ Duncker, RJ Bache - Physiological reviews, 2008 - journals.physiology.org
Exercise is the most important physiological stimulus for increased myocardial oxygen
demand. The requirement of exercising muscle for increased blood flow necessitates an …
demand. The requirement of exercising muscle for increased blood flow necessitates an …
Case report: Transplantation of human induced pluripotent stem cell-derived cardiomyocyte patches for ischemic cardiomyopathy
S Miyagawa, S Kainuma, T Kawamura… - Frontiers in …, 2022 - frontiersin.org
Despite major therapeutic advances, heart failure, as a non-communicable disease, remains
a life-threatening disorder, with 26 million patients worldwide, causing more deaths than …
a life-threatening disorder, with 26 million patients worldwide, causing more deaths than …
Hibernating myocardium
G Heusch - Physiological reviews, 1998 - journals.physiology.org
Heusch, Gerd. Hibernating Myocardium. Physiol. Rev. 78: 1055–1085, 1998.—Decreased
myocardial contraction occurs as a consequence of a reduction in blood flow. The concept of …
myocardial contraction occurs as a consequence of a reduction in blood flow. The concept of …
Myocardial hibernation: a delicate balance
The pathophysiology of myocardial hibernation is characterized as a situation of reduced
regional contractile function distal to a coronary artery stenosis that recovers after removal of …
regional contractile function distal to a coronary artery stenosis that recovers after removal of …
The representative porcine model for human cardiovascular disease
Y Suzuki, AC Yeung, F Ikeno - BioMed Research International, 2011 - Wiley Online Library
To improve human health, scientific discoveries must be translated into practical
applications. Inherent in the development of these technologies is the role of preclinical …
applications. Inherent in the development of these technologies is the role of preclinical …
Hibernating myocardium: chronically adapted to ischemia but vulnerable to sudden death
JM Canty Jr, G Suzuki, MD Banas, F Verheyen… - Circulation …, 2004 - Am Heart Assoc
The inability to reproduce spontaneous ventricular fibrillation in an animal model of chronic
coronary artery disease has limited advances in understanding mechanisms of sudden …
coronary artery disease has limited advances in understanding mechanisms of sudden …
The in-situ pig heart with regional ischemia/reperfusion—ready for translation
The pig heart in situ with regional myocardial ischemia and reperfusion is of unique
translational value. Cardiac size, heart rate and blood pressure are similar to those in …
translational value. Cardiac size, heart rate and blood pressure are similar to those in …
Program of cell survival underlying human and experimental hibernating myocardium
C Depre, SJ Kim, AS John, Y Huang… - Circulation …, 2004 - Am Heart Assoc
Hibernating myocardium refers to chronically dysfunctional myocardium in patients with
coronary artery disease in which cardiac viability is maintained and whose function …
coronary artery disease in which cardiac viability is maintained and whose function …
Translational physiology: porcine models of human coronary artery disease: implications for preclinical trials of therapeutic angiogenesis
“Therapeutic angiogenesis” describes an emerging field of cardiovascular medicine
whereby new blood vessels are induced to grow to supply oxygen and nutrients to ischemic …
whereby new blood vessels are induced to grow to supply oxygen and nutrients to ischemic …