Sepsis is one of the main reasons for intensive care unit admission and is responsible for
high morbidity and mortality. The usual hemodynamic targets for resuscitation of patients …

The vascular endothelium is crucial for the maintenance of vascular homeostasis. Moreover,
in sepsis, endothelial cells can acquire new properties and actively participate in the host's …

Rationale: Identification of cardiogenic shock severity is a critical step to adapt the
management level upon admission. Peripheral tissue perfusion signs, simple and reliable …

An international team of experts in the field of fluid resuscitation was invited by the ESICM to
form a task force to systematically review the evidence concerning fluid administration using …

Sufficient organ perfusion essentially depends on preserved macro-and micro-circulation.
The last two decades brought substantial progress in the development of less and non …

Objectives: This observational study was conducted to investigate capillary refill time (CRT)
during the early phase of ICU admission in relationship with microvascular flow alteration …

Background Mottling score, a tissue perfusion parameter, is correlated with outcome in
septic shock patients. However, its predictive value on mortality according to prognostic …

Background Persistent hyperlactatemia has been considered as a signal of tissue
hypoperfusion in septic shock patients, but multiple non-hypoperfusion-related pathogenic …

Objectives The early identification of septic shock patients at high risk of poor outcome is
essential to early initiate optimal treatments and to decide on hospital admission …

Single variables obtained by clinical examination should not be used when estimating CO.
Physician's educated guesses of CO based on unstructured clinical examination are like the …