Recent development of improved tools and methods to analyse tissues at the three-
dimensional level has expanded our capacity to investigate morphogenesis of foetal liver …

Vertebrates exhibit striking left–right (L–R) asymmetries in the structure and position of the
internal organs. Symmetry is broken by motile cilia-generated asymmetric fluid flow …

Understanding how left–right (LR) asymmetry is generated in vertebrate embryos is an
important problem in developmental biology. In humans, a failure to align the left and right …

Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …

The adult liver of most vertebrates is predominantly comprised of hepatocytes. However,
these cells must work in concert with biliary, stellate, vascular, and immune cells to …

Kupffer's vesicle (KV) is the zebrafish organ of laterality, patterning the embryo along its left-
right (LR) axis. Regional differences in cell shape within the lumen-lining KV epithelium are …

Positioning organs in the body often requires the movement of multiple tissues, yet the
molecular and cellular mechanisms coordinating such movements are largely unknown …

The zebrafish extracellular matrix (ECM) is a dynamic and pleomorphic structure consisting
of numerous proteins that together regulate a variety of cellular and morphogenetic events …

The first critical stage in salamander or teleost appendage regeneration is creation of a
specialized epidermis that instructs growth from underlying stump tissue. Here, we …

The liver is an indispensable organ for metabolism and drug detoxification. The liver
consists of endoderm-derived hepatobiliary lineages and various mesoderm-derived cells …