Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …

The human intestinal microbiome plays a major role in human health and diseases,
including colorectal cancer. Colorectal carcinogenesis represents a heterogeneous process …

Microsatellite instability (MSI) has been approved as a pan-cancer biomarker for immune
checkpoint blockade (ICB) therapy. However, current MSI identification methods are not …

Over the past three decades, molecular genetic studies have revealed some critical
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …

Microsatellites are short tandem repeat DNA sequences of one to tetra base pairs distributed
throughout the human genome, both in coding and non-coding regions. Owing to their …

Hereditary colorectal cancer (HCRC) accounts for< 5% of all colorectal cancer cases. Some
of the unique characteristics commonly encountered in HCRC cases include early age of …

Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …

The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to
assist health care providers with the appropriate provision of genetic testing and …

Purpose Identifying individuals with Lynch syndrome (LS) is highly beneficial. However, it is
unclear whether microsatellite instability (MSI) or immunohistochemistry (IHC) should be …

Abstract Mismatch Repair Deficiency (dMMR)/Microsatellite Instability (MSI) is a key
biomarker in colorectal cancer (CRC). Universal screening of CRC patients for MSI status is …