Neuro-orchestration of sleep and wakefulness
Although considered an inactive state for centuries, sleep entails many active processes
occurring at the cellular, circuit and organismal levels. Over the last decade, several key …
occurring at the cellular, circuit and organismal levels. Over the last decade, several key …
Cell and circuit complexity of the external globus pallidus
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation
Symptoms of neurological diseases emerge through the dysfunction of neural circuits whose
diffuse and intertwined architectures pose serious challenges for delivering therapies. Deep …
diffuse and intertwined architectures pose serious challenges for delivering therapies. Deep …
[HTML][HTML] The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding
C Varin, A Cornil, D Houtteman, P Bonnavion… - Nature …, 2023 - nature.com
The basal ganglia are known to control actions and modulate movements. Neuronal activity
in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral …
in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral …
The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression
Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
Understanding the neural mechanisms of general anesthesia from interaction with sleep–wake state: a decade of discovery
WW Bao, S Jiang, WM Qu, WX Li, CH Miao… - Pharmacological …, 2023 - ASPET
The development of cutting-edge techniques to study specific brain regions and neural
circuits that regulate sleep–wake brain states and general anesthesia (GA), has increased …
circuits that regulate sleep–wake brain states and general anesthesia (GA), has increased …
A common hub for sleep and motor control in the substantia nigra
The arousal state of the brain covaries with the motor state of the animal. How these state
changes are coordinated remains unclear. We discovered that sleep–wake brain states and …
changes are coordinated remains unclear. We discovered that sleep–wake brain states and …
A motor theory of sleep-wake control: arousal-action circuit
Wakefulness, rapid eye movement (REM) sleep, and non–rapid eye movement (NREM)
sleep are characterized by distinct electroencephalogram (EEG), electromyogram (EMG) …
sleep are characterized by distinct electroencephalogram (EEG), electromyogram (EMG) …
[HTML][HTML] Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway
The ventral pallidum (VP) regulates motivation, drug addiction, and several behaviors that
rely on heightened arousal. However, the role and underlying neural circuits of the VP in the …
rely on heightened arousal. However, the role and underlying neural circuits of the VP in the …
[HTML][HTML] Connectivity and functionality of the globus pallidus externa under normal conditions and Parkinson's disease
The globus pallidus externa (GPe) functions as a central hub in the basal ganglia for
processing motor and non-motor information through the creation of complex connections …
processing motor and non-motor information through the creation of complex connections …