Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …

Sexual differentiation of malaria parasites from the asexual blood stage into gametocytes is
an essential part of the life cycle, as gametocytes are the form that is taken up by the …

Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and
subsequent gamete fertilization in mosquitoes is essential for the spreading of the disease …

The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic
persistence in human red blood cells, continuously evading host immunity using …

Malaria transmission to mosquitoes requires a developmental switch in asexually dividing
blood-stage parasites to sexual reproduction. In Plasmodium berghei, the transcription factor …

While gene expression is a fundamental and tightly controlled cellular process that is
regulated at multiple steps, the exact contribution of each step remains unknown in any …

Malaria remains one of the leading causes of death worldwide, despite decades of public
health efforts. The recent commitment by many endemic countries to eliminate malaria …

DNA modifications are critical in fine-tuning the biological processes in model organisms.
However, the presence of cytosine methylation (5mC) and the function of the putative DNA …

Success in eliminating malaria will depend on whether parasite evolution outpaces control
efforts. Here, we show that Plasmodium falciparum parasites (the deadliest of the species …

The histone acetyltransferase GCN5-associated SAGA complex is evolutionarily conserved
from yeast to human and functions as a general transcription co-activator in global gene …