Voltage-gated sodium (Na V) channels initiate action potentials in nerve, muscle, and other
electrically excitable cells. The structural basis of voltage gating is uncertain because the …

In excitable cells, the main mediators of sodium conductance across membranes are voltage-
gated sodium channels (NaVs). Eukaryotic NaVs are essential elements in neuronal …

Neural activity plays roles in the later stages of development of cortical excitatory neurons,
including dendritic and axonal arborization, remodeling, and synaptogenesis. However, its …

Activation and inactivation of voltage-gated sodium channels (Navs) are well studied, yet the
molecular mechanisms governing channel gating in the membrane remain unknown. We …

Voltage-dependent Ca2+ channels (Cavs) are indispensable for coupling action potentials
with Ca2+ signaling in living organisms. The structure of Cavs is similar to that of voltage …

The ability to directly enhance electrical excitability of human cells is hampered by the lack
of methods to efficiently overexpress large mammalian voltage-gated sodium channels …

Computational methods and experimental data are used to provide structural models for
NaChBac, the homo-tetrameric voltage-gated sodium channel from the bacterium Bacillus …

Voltage‐gated sodium channels are crucial for electro‐signalling in living systems. Analysis
of the molecular mechanism requires both fine electrophysiological evaluation and high …

Eukaryotic sodium channels are important membrane proteins involved in ion permeation,
homeostasis, and electrical signaling. They are long, multidomain proteins that do not …

Saxitoxin is a secondary metabolite produced by several species of dinoflagellates and
cyanobacteria which targets voltage-gated sodium and potassium channels in higher …