The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Cardiac optical mapping has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well …

Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder
linked to arrhythmia and sudden cardiac death. While the causes of HCM have been …

Spontaneous local increases in the concentration of intracellular calcium, called" calcium
sparks," were detected in quiescent rat heart cells with a laser scanning confocal …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

A mathematical model of the cardiac ventricular action potential is presented. In our previous
work, the membrane Na+ current and K+ currents were formulated. The present article …

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic
reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross-talk …

▪ Abstract Calcium-activated chloride channels (CaCCs) play important roles in cellular
physiology, including epithelial secretion of electrolytes and water, sensory transduction …

The consequences of cardiac excitation-contraction coupling by calcium-induced calcium
release were studied theoretically, using a series of idealized models solved by analytic and …

The action potential model presented in our accompanying article in this journal is used to
investigate phenomena that involve dynamic changes of [Ca2+] i, as described below …