The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

There are two basic categories of pain: physiological pain, which serves an important
protective function, and pathological pain, which can have a major negative impact on …

Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as
well as a loss of sensation in the areas in which injured and non-injured nerves come …

Neuropathic pain remains a pressing clinical problem. Here, we demonstrate that a local,
intrathecal (it) injection of bone marrow stromal cells (BMSCs) following lumbar puncture …

AMPA receptors mediate fast excitatory neurotransmission and are critical for CNS
development and function. Calcium-permeable subsets of AMPA receptors are strongly …

Chronic pain is a frequent, distressing and poorly understood health problem. Plasticity of
synaptic transmission in the nociceptive pathways after inflammation or injury is assumed to …

Persistent pain induced by noxious stimuli is characterized by the transition from
normosensitivity to hypersensitivity. Underlying mechanisms are not well understood …

Mechanisms underlying central neuropathic pain are poorly understood. Although glial
dysfunction has been functionally linked with neuropathic pain, very little is known about …

Wnt signaling represents a highly versatile signaling system, which plays critical roles in
developmental morphogenesis as well as synaptic physiology in adult life and is implicated …

The molecular composition of the cannabinoid type 1 (CB1) receptor complex beyond the
classical G-protein signaling components is not known. Using proteomics on mouse cortex …