Metabolic syndrome poses a major threat on human health affecting the quality of life.
Adipose tissue is an important organ which plays a crucial role in the pathogenesis of …

Digestive disorders (diarrhoea, vomiting) represent the most common metformin side-effects
(around 30%) with this first-line drug treatment for type 2 diabetes. In healthy individuals …

Impaired mitochondrial respiratory activity contributes to the development of insulin
resistance in type 2 diabetes. Metformin, a first-line antidiabetic drug, functions mainly by …

D-Allulose is a rare sugar that exists in nature. It is a food ingredient with nearly zero calories
(< 0.4 kcal/g) and has many physiological functionalities such as attenuation of postprandial …

Abstract Treatment of diabetics with metformin is associated with decreased breast cancer
risk in observational studies, but it remains unclear if this drug has clinical antineoplastic …

Aim To investigate whether appetite‐related hormones were predictors of weight regain in
the Diabetes Remission Clinical Trial (DiRECT). Materials and Methods DiRECT is a cluster …

Ghrelin is the only known peripherally produced and centrally acting peptide hormone
stimulating food intake. The acylation of ghrelin is essential for binding to its receptor …

We performed this meta-analysis to investigate and determine the role of metformin on
serum adiponectin levels in Type 2 diabetes (T2DM) patients. Embase, Web of Science …

Introduction: Several peptides are involved in the regulation of food intake and energy
expenditure, among which are leptin, adiponectin, ghrelin and neuropeptide Y (NPY). These …

Background/Aims: The antihyperglycaemic drug metformin reduces food consumption
through mechanisms that are not fully elucidated. The present study investigated the effects …