Iron is the most abundant transition metal in the human body and its bioavailability is
stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to …

Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host
macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation …

Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this
protection is due to direct inhibition of Mycobacterium tuberculosis growth, which prevents …

We report the discovery of a series of new drug leads that have potent activity against
Mycobacterium tuberculosis as well as against other bacteria, fungi, and a malaria parasite …

Multidrug resistant (MDR) bacteria are a global threat with many common infections
becoming increasingly difficult to eliminate. While significant effort has gone into the …

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Modern chemotherapy has significantly improved patient outcomes against drug-sensitive
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …

Our team had previously identified certain indolecarboxamides that represented a new
chemical scaffold that showed promising anti-TB activity at both an in vitro and in vivo level …

The recent accelerated approval for use in extensively drug-resistant and multidrug-resistant-
tuberculosis (MDR-TB) of two first-in-class TB drugs, bedaquiline and delamanid, has …

Rapidly spreading antibiotic resistance and the low discovery rate of new antimicrobial
compounds demand more effective strategies for early drug discovery. One bottleneck in the …