Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow

MJP van Osch, WM Teeuwisse… - Journal of Cerebral …, 2018 - journals.sagepub.com
With the publication in 2015 of the consensus statement by the perfusion study group of the
International Society for Magnetic Resonance in Medicine (ISMRM) and the EU-COST …

Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging

T Lindner, DS Bolar, E Achten, F Barkhof… - Magnetic resonance …, 2023 - Wiley Online Library
This article focuses on clinical applications of arterial spin labeling (ASL) and is part of a
wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) …

Neuroimaging of vascular reserve in patients with cerebrovascular diseases

MR Juttukonda, MJ Donahue - Neuroimage, 2019 - Elsevier
Cerebrovascular reactivity, defined broadly as the ability of brain parenchyma to adjust
cerebral blood flow in response to altered metabolic demand or a vasoactive stimulus, is …

[HTML][HTML] ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies

HJMM Mutsaerts, J Petr, P Groot, P Vandemaele… - Neuroimage, 2020 - Elsevier
Arterial spin labeling (ASL) has undergone significant development since its inception, with
a focus on improving standardization and reproducibility of its acquisition and quantification …

Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia

KP Guilliams, ME Fields, DK Ragan… - Blood, The Journal …, 2018 - ashpublications.org
Blood transfusions are the mainstay of stroke prevention in pediatric sickle cell anemia
(SCA), but the physiology conferring this benefit is unclear. Cerebral blood flow (CBF) and …

Diminished cerebral oxygen extraction and metabolic rate in sickle cell disease using T2 relaxation under spin tagging MRI

AM Bush, TD Coates, JC Wood - Magnetic resonance in …, 2018 - Wiley Online Library
Purpose T2 MRI oximetry can noninvasively determine oxygen saturation (Y) but requires
empirical MR calibration models to convert the measured blood transverse relaxation (T2b) …

Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia

ME Fields, KP Guilliams, D Ragan… - Blood, The Journal …, 2019 - ashpublications.org
Chronic transfusion therapy (CTT) prevents stroke in selected patients with sickle cell
anemia (SCA). We have shown that CTT mitigates signatures of cerebral metabolic stress …

Hemodynamic provocation with acetazolamide shows impaired cerebrovascular reserve in adults with sickle cell disease

L Václavů, BN Meynart, HJMM Mutsaerts… - …, 2018 - pmc.ncbi.nlm.nih.gov
Sickle cell disease is characterized by chronic hemolytic anemia and vascular inflammation,
which can diminish the vasodilatory capacity of the small resistance arteries, making them …

Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications

JG Woods, E Achten, I Asllani, DS Bolar… - Magnetic resonance …, 2024 - Wiley Online Library
Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic
processes involved in various neurological disorders and guiding clinical decision‐making …

White matter has impaired resting oxygen delivery in sickle cell patients

Y Chai, AM Bush, J Coloigner… - American journal of …, 2019 - Wiley Online Library
Although modern medical management has lowered overt stroke occurrence in patients with
sickle cell disease (SCD), progressive white matter (WM) damage remains common. It is …