Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

The approval of BTK and PI3K inhibitors (ibrutinib, idelalisib) represents a revolution in the
therapy of B cell malignancies such as chronic lymphocytic leukemia (CLL), mantle-cell …

The therapy of relapsed chronic lymphocytic leukemia (CLL) has changed dramatically in
the past year with the regulatory approval of idelalisib and ibrutinib, with other therapeutic …

Notch and Wnt signaling are highly conserved intercellular communication pathways
involved in developmental processes, such as hematopoiesis. Even though data from …

Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and
benign. Due to its high prevalence, it is, however, still the second most common cause of …

The recruitment of signaling proteins into activated receptor tyrosine kinases (RTKs) to
produce rapid, high-fidelity downstream response is exposed to the ambiguity of random …

Acute myeloid leukemia (AML) cells exhibit a high level of spontaneous apoptosis when
cultured in vitro but have a prolonged survival time in vivo, indicating that tissue …

The Wnt signalling pathway, one of the core de-regulated pathways in chronic lymphocytic
leukaemia (CLL), is activated in only a subset of patients through somatic mutations. Here …

Simple Summary Nowadays, many patients with chronic lymphocytic leukemia (CLL) are
treated with so-called novel agents, including BTK inhibitors, Bcl-2 inhibitors and PI3K …