Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

The field of angiogenesis research has primarily focused on the mechanisms of sprouting
angiogenesis. Yet vascular networks formed by vessel sprouting subsequently undergo …

Patterning of functional blood vessel networks is achieved by pruning of superfluous
connections. The cellular and molecular principles of vessel regression are poorly …

1. From avascular to vascular It is clear that for vasculogenesis and angiogenesis to
effectively proceed during physiological and pathological From the earliest stages, the …

Modulation of Tie2 receptor activity by its angiopoietin ligands is crucial for angiogenesis,
blood vessel maturation, and vascular endothelium integrity. It has been proposed that …

As blood flows, the vascular wall is constantly subjected to physical forces, which regulate
important physiological blood vessel responses, as well as being implicated in the …

Angiogenesis inhibitors are receiving increased attention as cancer therapeutics, but little is
known of the cellular effects of these inhibitors on tumor vessels. We sought to determine …

Arterial hypertension (HT) has been reported in all studies involving bevacizumab, an
antiangiogenic agent designed to target vascular endothelial growth factor (VEGF). The …

The vasculature of the embryo requires vascular endothelial growth factor (VEGF) during
development, but most adult blood vessels lose VEGF dependence. However, some …

Vascular patterning is critical for organ function. In the eye, there is simultaneous regression
of embryonic hyaloid vasculature (important to clear the optical path) and formation of the …