Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

Abstract AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic
glutamate receptors mediate fast excitatory neurotransmission throughout the central …

The nitrile group is an important functional group widely found in both pharmaceutical
agents and natural products. More than 30 nitrile-containing pharmaceuticals have been …

Monday, February 19, 2018 303a neuronal excitability, respond to lipids, temperature and
mechanical stretch, and influence pain, temperature perception and anaesthetic responses …

Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …

Glutamate receptor-like channels (GLRs) play vital roles in various physiological processes
in plants, such as wound response, stomatal aperture control, seed germination, root …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in
synaptic transmission and plasticity. Both hyper‐and hypo‐activation of NMDARs are …

Homeostatic plasticity (HP) encompasses a suite of compensatory physiological processes
that counteract neuronal perturbations, enabling brain resilience. Currently, we lack a …