Simple Summary The development of uveal melanoma is a multifactorial and multi-step
process, in which specific and recurrent mutations arise early. Among the recurrently …

Patient-derived xenograft (PDX) models are used as powerful tools for understanding
cancer biology in PDX clinical trials and co-clinical trials. In this systematic review, we focus …

Among Uveal Melanoma (UM) driver mutations, those involving GNAQ or GNA11 genes are
the most frequent, while a minor fraction of tumors bears mutations in the PLCB4 or …

Among the numerous immune interactions, or lack-thereof, that occur during cancer
progression, tumor-associated macrophages (TAMs)–cancer cell interactions have been …

Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the
liver. Despite the identification of the early driver mutations during the development of the …

Purpose: Mutational activation of GNAQ or GNA11 (GNAQ/11), detected in> 90% of uveal
melanomas, leads to constitutive activation of oncogenic pathways, including MAPK and …

Uveal melanoma (UM) is the most common intraocular malignancy in adults. So far, no
systemic therapy or standard treatment exists to reduce the risk of metastasis and improve …

Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Unfortunately, metastasis develops in up to 50% of cases and outcomes are poor for …

Simple Summary Uveal melanoma is a deadly form of eye cancer with a high rate of
metastasis. Once metastasis occurs, patients are often left with a short survival time, since …

Simple Summary Uveal Melanoma (UM) is a rare and malignant intraocular tumor with
dismal prognosis. Despite efficient control of the primary tumor by radiation or surgery, up to …