The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems
Diseases that result in retinal pigment epithelium (RPE) degeneration, such as age-related
macular degeneration (AMD), are among the leading causes of blindness worldwide …
macular degeneration (AMD), are among the leading causes of blindness worldwide …
[HTML][HTML] Understanding drivers of ocular fibrosis: current and future therapeutic perspectives
Ocular fibrosis leads to severe visual impairment and blindness worldwide, being a major
area of unmet need in ophthalmology and medicine. To date, the only available treatments …
area of unmet need in ophthalmology and medicine. To date, the only available treatments …
[HTML][HTML] Targeting the Notch and TGF-β signaling pathways to prevent retinal fibrosis in vitro and in vivo
J Fan, W Shen, SR Lee, AE Mathai, R Zhang, G Xu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Rationale: The Notch and transforming growth factor-β (TGFβ) signaling pathways
are two intracellular mechanisms that control fibrosis in general but whether they play a …
are two intracellular mechanisms that control fibrosis in general but whether they play a …
[HTML][HTML] Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory …
Introduction Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are
leading causes of visual impairment and blindness in people aged 50 years or older in …
leading causes of visual impairment and blindness in people aged 50 years or older in …
Retinal cell transplantation, biomaterials, and in vitro models for developing next-generation therapies of age-related macular degeneration
LJ Rizzolo, IO Nasonkin… - Stem Cells Translational …, 2022 - academic.oup.com
Retinal pigment epithelium (RPE) cells grown on a scaffold, an RPE patch, have potential to
ameliorate visual impairment in a limited number of retinal degenerative conditions. This …
ameliorate visual impairment in a limited number of retinal degenerative conditions. This …
[HTML][HTML] Vitreous humor proteome: unraveling the molecular mechanisms underlying proliferative and neovascular vitreoretinal diseases
FM Dos Santos, S Ciordia, J Mesquita… - Cellular and Molecular …, 2023 - Springer
Proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and
neovascular age-related macular degeneration (nAMD) are among the leading causes of …
neovascular age-related macular degeneration (nAMD) are among the leading causes of …
[HTML][HTML] Vitreous humor proteome: targeting oxidative stress, inflammation, and neurodegeneration in vitreoretinal diseases
Oxidative stress is defined as an unbalance between pro-oxidants and antioxidants, as
evidenced by an increase in reactive oxygen and reactive nitrogen species production over …
evidenced by an increase in reactive oxygen and reactive nitrogen species production over …
SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress
Retinal pigment epithelium (RPE) is essential for the survival of retinal photoreceptors. To
study retinal degeneration, sodium iodate (NaIO3) has been used to cause oxidative stress …
study retinal degeneration, sodium iodate (NaIO3) has been used to cause oxidative stress …
[HTML][HTML] Proliferative vitreoretinopathy: a reappraisal
P Carpineto, AM Licata, M Ciancaglini - Journal of Clinical Medicine, 2023 - mdpi.com
Proliferative vitreoretinopathy (PVR) remains the main cause of failure after retinal
detachment (RD) surgery. Despite the development of modern technologies and …
detachment (RD) surgery. Despite the development of modern technologies and …
[HTML][HTML] A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway
One common cause of vision loss after retinal detachment surgery is the formation of
proliferative and contractile fibrocellular membranes. This aberrant wound healing process …
proliferative and contractile fibrocellular membranes. This aberrant wound healing process …