Objective: The authors conducted a systematic review and meta-analysis of ketamine and
other N-methyl-d-aspartate (NMDA) receptor antagonists in the treatment of major …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Major depressive disorder (MDD) is a severe, debilitating medical illness that affects millions
of individuals worldwide. The young age of onset and chronicity of the disorder has a …

Ample evidence indicates that glutamate homeostasis and neurotransmission are disrupted
in major depressive disorder; but the nature of this disruption and the mechanisms by which …

To determine whether neuropsychiatric manifestations in patients with systemic lupus
erythematosus (SLE) are influenced by antibodies against the human N‐methyl‐d‐aspartate …

For a number of patients with bipolar disorder, current pharmacotherapy is generally
insufficient. Despite adequate treatment, patients continue to have recurrent mood episodes …

Monoaminergic pathways are highly responsive to aversive stimuli and play a crucial role in
the control of affect, cognition, endocrine secretion, chronobiotic rhythms, appetite, and …

Down syndrome (DS), also known as trisomy 21, is the most common genetic cause of
intellectual disability (ID). Although ID can be mild, the average intelligence quotient is in the …

The past decade of efforts to find improved treatment for major depression has been
dominated by genome-driven programs of rational drug discovery directed toward highly …

Memantine received marketing authorization from the European Agency for the Evaluation
of Medicinal Products (EMEA) for the treatment of moderately severe to severe Alzheimer's …