The serine/threonine kinase, PINK1, and the E3 ubiquitin ligase, Parkin, are known to
facilitate LC3-dependent autophagosomal encasement and lysosomal clearance of …

The extracellular matrix (ECM) plays important roles in maintaining physiological structure
and functions of various tissues and organs. Cardiac fibrosis is the excess deposition of …

Despite the many advantages of isoproterenol (Iso)-induced models of cardiomyopathy, the
extant literature suggests that the reproducibility of the Iso-induced stress cardiomyopathy …

Cancer survivors may experience long-term cardiovascular complications due to
chemotherapeutic drugs such as doxorubicin (DOX). The exact mechanism of delayed DOX …

Background: Catecholamine surges and resultant excessive β-adrenergic stimulation occur
in a broad spectrum of diseases. Excessive β-adrenergic stimulation causes cardiomyocyte …

The aging heart is well-characterized by a diminished responsiveness to adrenergic
activation. However, the precise mechanisms by which age and sex impact adrenergic …

We studied by conventional and speckle-tracking echocardiography, the response of the left
ventricle (LV) to a three-week continuous infusion of isoproterenol (Iso), a non-specific beta …

Sex is a salient risk factor in the development of doxorubicin-induced cardiotoxicity. Sex
differences in the heart's ability to respond to hypertrophic stimuli in doxorubicin-exposed …

Aim Chronic sympathetic stimulation has been identified as a primary factor in the
pathogenesis of cardiac hypertrophy (CH). However, there is no appropriate treatment …

Heart Failure (HF) continues to be a complex public health issue with increasing world
population prevalence. Although overall mortality has decreased for HF and hypertrophic …