Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects
By controlling several antioxidant and detoxifying genes at the transcriptional level,
including NAD (P) H quinone oxidoreductase 1 (NQO1), multidrug resistance-associated …
including NAD (P) H quinone oxidoreductase 1 (NQO1), multidrug resistance-associated …
[HTML][HTML] Suppression of TRPV1/TRPM8/P2Y nociceptors by withametelin via downregulating MAPK signaling in mouse model of vincristine-induced neuropathic pain
Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …
Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy
This study aimed to investigate the anti-neuropathic pain activity and its underlying
molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The …
molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The …
Withametelin, a novel phytosterol, alleviates neurological symptoms in EAE mouse model of multiple sclerosis via modulation of Nrf2/HO-1 and TLR4/NF-κB signaling
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central
nervous system (CNS) that remains incurable. Withametelin (WMT), a phytosterol, showed …
nervous system (CNS) that remains incurable. Withametelin (WMT), a phytosterol, showed …
[HTML][HTML] Anti-inflammatory and analgesic potential of leaf extract of Justicia adhatoda L.(Acanthaceae) in Carrageenan and Formalin-induced models by targeting …
A Basit, T Shutian, A Khan, SM Khan… - Biomedicine & …, 2022 - Elsevier
Plants are regarded as a valuable and inexpensive source of new drug development, and a
variety of plant compounds are now being used in clinical trials to treat a variety of ailments …
variety of plant compounds are now being used in clinical trials to treat a variety of ailments …
Diacerein attenuate LPS-induced acute lung injury via inhibiting ER stress and apoptosis: Impact on the crosstalk between SphK1/S1P, TLR4/NFκB/STAT3, and …
NS Youssef, AS Elzaitony, NAA Baky - Life Sciences, 2022 - Elsevier
Aims Acute lung injury (ALI) is a life-threatening clinical problem with high mortality rate and
limited treatments or preventive options that represents a major challenge for clinicians …
limited treatments or preventive options that represents a major challenge for clinicians …
Withametelin, a steroidal lactone, isolated from datura innoxa attenuates STZ-induced diabetic neuropathic pain in rats through inhibition of NF-kB/MAPK signaling
Diabetic neuropathic pain is one of the microvascular complications of diabetes mellitus
characterized by symmetrical pain and sensory abnormalities. A steroidal lactone isolated …
characterized by symmetrical pain and sensory abnormalities. A steroidal lactone isolated …
Anti-nociceptive effects of magnolol via inhibition of TRPV1/P2Y and TLR4/NF-κB signaling in a postoperative pain model
Aims The current study explored the anti-nociceptive activity of magnolol in post-incisional
inflammatory nociceptive pain. Main methods Preliminary, the anti-inflammatory, antioxidant …
inflammatory nociceptive pain. Main methods Preliminary, the anti-inflammatory, antioxidant …
Neuroprotective mechanism of Ajugarin-I against Vincristine-Induced neuropathic pain via regulation of Nrf2/NF-κB and Bcl2 signalling
Vincristine (VCR) is a well-known chemotherapeutic agent that frequently triggers
neuropathic pain. Ajugarin-I (Aju-I) isolated from Ajuga bracteosa exerts antioxidant, anti …
neuropathic pain. Ajugarin-I (Aju-I) isolated from Ajuga bracteosa exerts antioxidant, anti …
[HTML][HTML] Anti-inflammatory and anti-rheumatic potential of selective plant compounds by targeting TLR-4/AP-1 signaling: A comprehensive molecular docking and …
Plants are an important source of drug development and numerous plant derived molecules
have been used in clinical practice for the ailment of various diseases. The Toll-like receptor …
have been used in clinical practice for the ailment of various diseases. The Toll-like receptor …