Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia.
It can linger for many years, but ultimately is fatal, the 6th leading cause of death …

Alzheimer's disease (AD) is the disease of lost memories. Synaptic loss is a major reason for
memory defects in AD. Signaling pathways involved in memory loss in AD are under intense …

Intracerebral injection of brain extracts containing amyloid or tau aggregates in transgenic
animals can induce cerebral amyloidosis and tau pathology. We extracted pure populations …

Senile plaques are a prominent pathological feature of Alzheimer's disease (AD), but little is
understood about the association of glial cells with plaques or about the dynamics of glial …

Astrocytes are the most abundant cell type in the brain and play a critical role in maintaining
healthy nervous tissue. In Alzheimer's disease (AD) and most other neurodegenerative …

In Alzheimer's disease (AD) basic research and drug discovery, mouse models are essential
resources for uncovering biological mechanisms, validating molecular targets and screening …

Synaptic proteomes have evolved a rich and complex diversity to allow the exquisite control
of neuronal communication and information transfer. It is therefore not surprising that many …

Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of
nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's …

Major brain functions depend on neuronal processes that favor the plasticity of neuronal
circuits while at the same time maintaining their stability. The mechanisms that regulate …

The oligomer hypothesis for Alzheimer's disease (AD) was introduced in 1998. It was based
on evidence that oligomers could exist free of amyloid fibrils, that fibril-free oligomer …