Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single …

The airway epithelium occupies a critical environmental interface, protecting the host from a
wide variety of inhaled insults, including chemical and particulate pollutants and pathogens …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR). Newly developed “correctors” such as lumacaftor (VX-809) that improve CFTR …

▪ Abstract Calcium-activated chloride channels (CaCCs) play important roles in cellular
physiology, including epithelial secretion of electrolytes and water, sensory transduction …

Cystic Fibrosis (CF) lung disease, which is characterized by airway obstruction, chronic
bacterial infection, and an excessive inflammatory response, is responsible for most of the …

Ca2+-activated Cl− channels (CaCCs) are exceptionally well adapted to subserve diverse
physiological roles, from epithelial fluid transport to sensory transduction, because their …

For almost two decades, it has been postulated that calcium-activated Cl–channels (CaCCs)
play a role in airway epithelial Cl–secretion, but until recently, the molecular identity of the …

Calcium-activated chloride channels (CaCCs) are widely expressed in mammalian tissues,
including intestinal epithelia, where they facilitate fluid secretion. Potent, selective CaCC …