Functions and properties of native peptides vary from highly specific antibiotics or cytotoxic
antitumor drugs, to hormones, neurotransmitters, immunomodulators, etc. Despite their …

In this critical review, the progress in catalytic asymmetric synthesis of β-amino acids is
discussed, covering the literature since 2002. The review treats transition metal catalysis …

β-Amino acids are useful building blocks of bioactive molecules, including peptidomimetics
and pharmaceutical compounds. The current limited accessibility to β2, 2-type amino acids …

The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

β2-Amino carbonyls, an α-substituted β-amino scaffold, hold a prominent place in the
development of new pharmaceuticals and peptidomimetics. Herein, we report a highly …

Dual photoredox–transition-metal catalysis has emerged as a powerful tool for the
development of chemical transformations. However, its application in the selective …

Cationic Ir (I)-complexes modified with homochiral diphosphines promote the
hydroalkenylative cross-coupling of β-(arylamino) acrylates with monosubstituted styrenes …

β-Amino acid derivatives are key structural elements in synthetic and biological chemistry.
Despite being a hallmark method for their preparation, the direct Mannich reaction …

Enantiopure fluorine containing β-amino acids are of large biological and pharmaceutical
interest. Strategies to prepare β-amino acid derivatives possessing a F-containing …

We report here a scalable, catalytic one-pot approach to enantiopure and unmodified β2-
amino acids. A newly developed confined imidodiphosphorimidate (IDPi) catalyzes a …