A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an
intact immune system, but the complex mechanisms regulating tumor immunogenicity have …

Epigenetic reprogramming is a critical process of pathological gene induction during cardiac
hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be …

Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute
myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been …

Ovarian cancer has a clear predilection for metastasis to the omentum, but the underlying
mechanisms involved in ovarian cancer spread are not well understood. Here, we used a …

Drug discovery and development (DDD) is a highly complex process that necessitates
precise monitoring and extensive data analysis at each stage. Furthermore, the DDD …

Metabolic heterogeneity is a key factor in cancer pathogenesis. We found that a subset of
BRAF-and NRAS-mutant human melanomas resistant to the MEK inhibitor selumetinib …

Stress is integral to tumour evolution, and cancer cell survival depends on stress
management. We found that cancer-associated stress chronically activates the bioenergetic …

Motivation The analysis of high-dimensional 'omics data is often informed by the use of
biological interaction networks. For example, protein–protein interaction networks have …

Context-specific molecular vulnerabilities that arise during tumor evolution represent an
attractive intervention target class. However, the frequency and diversity of somatic lesions …