G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and
synthetic ligands, represent the largest family of druggable targets in the human genome …

The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …

Classically, G protein-coupled receptor (GPCR) stimulation promotes G protein signaling at
the plasma membrane, followed by rapid β-arrestin-mediated desensitization and receptor …

Control of protein levels by nucleic-acid-based technologies has proven to be a useful
research tool but lacks the advantages of small molecules with respect to cell permeability …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Diabetes insipidus (DI) is a disorder characterized by excretion of large amounts of
hypotonic urine. Central DI results from a deficiency of the hormone arginine vasopressin …

Endocytosis and intracellular trafficking of receptors are pivotal to maintain physiological
functions and drug action; however, robust quantitative approaches are lacking to study …

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a
cellular stress induced by multiple stimuli and pathological conditions. These include …

The endoplasmic reticulum (ER) has a quality-control system for'proof-reading'newly
synthesized proteins, so that only native conformers reach their final destinations. Non …

Healthy kidneys maintain fluid and electrolyte homoeostasis by adjusting urine volume and
composition according to physiological needs. The final urine composition is determined in …