For the last several decades, the standard of care for the initial management of rheumatoid
arthritis (RA) has been methotrexate. Methotrexate is effective as monotherapy and in …

Dose-limiting toxicities (DLTs) are severe adverse effects that define the maximum tolerated
dose of a cancer drug. In addition to the specific mechanisms of each drug, common …

Importance Low-dose methotrexate is used to treat rheumatoid arthritis and psoriasis. Due to
its kidney elimination, better evidence is needed to inform its safety in adults with chronic …

Background: Limited information exists on the risk of adverse events (AEs) attributed to
methotrexate (MTX) and biologics for the treatment of psoriasis/psoriatic arthritis (PsA/PsO) …

Introduction Chronic kidney disease (CKD) is a common comorbidity of rheumatoid arthritis
(RA). The association of longitudinal RA disease activity with long-term kidney function has …

Uric acid is a toxin retained with advancing kidney disease. Clinical manifestations of
hyperuricemia include gout and systemic inflammation that are associated with increased …

Purpose Osteosarcoma is a rare tumor with an incidence of 4.4 cases per million per year in
adolescent. High-dose methotrexate (HD-MTX) is the standard first-line chemotherapeutic …

Objectives To explore the toxicity of low-dose methotrexate (MTX), an uncommon, but life-
threatening event. Methods We analysed the presentation, course and risk factors of all …

Ревматоидный артрит (РА)-наиболее частое иммуновоспалительное (аутоиммунное)
ревматическое заболевание, характеризующееся хроническим эрозивным артритом и …

Introduction Upadacitinib (UPA) is a Janus kinase inhibitor that has demonstrated efficacy in
moderate-to-severe rheumatoid arthritis (RA) with an acceptable safety profile. We …