Creutzfeldt–Jakob disease (CJD) is a rapidly progressive, fatal and transmissible
neurodegenerative disease associated with the accumulation of misfolded prion protein in …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Covid-19 in Immune-Mediated Inflammatory Diseases The authors describe patients in New
York City with known immune-mediated inflammatory disease in whom Covid-19 developed …

Background YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by
inflammatory, cancer and stem cells. Its physiological role is not completely understood but …

Abstract Although Bovine Spongiform Encephalopathy (BSE) is the cause of variant
Creutzfeldt Jakob disease (vCJD) in humans, the zoonotic potential of scrapie prions …

Transmissible spongiform encephalopathies (TSEs) or prion diseases of animals notably
include scrapie in small ruminants, chronic wasting disease (CWD) in cervids and classical …

Prions are infectious pathogens essentially composed of PrPSc, an abnormally folded form
of the host-encoded prion protein PrPC. Constrained steric interactions between PrPSc and …

Variant CJD in a Laboratory Technician Variant Creutzfeldt–Jakob disease was identified in
a technician who had cut her thumb while handling brain sections of mice infected with …

The emergence of variant Creutzfeldt Jakob Disease (vCJD) is considered a likely
consequence of human dietary exposure to Bovine Spongiform Encephalopathy (BSE) …

Atypical/Nor98 scrapie (AS) is a prion disease of small ruminants. Currently there are no
efficient measures to control this form of prion disease, and, importantly, the zoonotic …