Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy
characterized by aberrant proliferation of immature thymocytes. Despite an overall survival …

T-cell acute lymphoblastic leukemias (T-ALL) are immature lymphoid tumors localizing in the
bone marrow, mediastinum, central nervous system, and lymphoid organs. They account for …

Background Chimeric antigen receptor (CAR) T-cell therapy using brexucabtagene
autoleucel (BA) induces remission in many patients with mantle cell lymphoma (MCL), and …

Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-
of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL) …

The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of
serine/threonine kinases that regulates numerous signaling networks that promote cell …

Protein kinase inhibitors are amongst the most successful cancer treatments, but targetable
kinases activated by genomic abnormalities are rare in T cell acute lymphoblastic leukemia …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy
with a dismal prognosis related to refractory/relapsing diseases, raising the need for new …

Abstract Interleukin-7 (IL-7) supports the growth and chemoresistance of T-cell acute
lymphoblastic leukemia (T-ALL), particularly the early T-cell precursor subtype (ETP-ALL) …