Natural rewards, neuroplasticity, and non-drug addictions
CM Olsen - Neuropharmacology, 2011 - Elsevier
There is a high degree of overlap between brain regions involved in processing natural
rewards and drugs of abuse.“Non-drug” or “behavioral” addictions have become …
rewards and drugs of abuse.“Non-drug” or “behavioral” addictions have become …
[HTML][HTML] Sensation-seeking: Dopaminergic modulation and risk for psychopathology
Sensation-seeking (SS) is a personality trait that refers to individual differences in motivation
for intense and unusual sensory experiences. It describes a facet of human behaviour that …
for intense and unusual sensory experiences. It describes a facet of human behaviour that …
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits
DR Sparta, AM Stamatakis, JL Phillips, N Hovelsø… - Nature protocols, 2012 - nature.com
In vivo optogenetic strategies have redefined our ability to assay how neural circuits govern
behavior. Although acutely implanted optical fibers have previously been used in such …
behavior. Although acutely implanted optical fibers have previously been used in such …
[HTML][HTML] Ventral hippocampal afferents to nucleus accumbens encode both latent vulnerability and stress-induced susceptibility
Background Stress is a major risk factor for depression, but not everyone responds to stress
in the same way. Identifying why certain individuals are more susceptible is essential for …
in the same way. Identifying why certain individuals are more susceptible is essential for …
Role of cues and contexts on drug‐seeking behaviour
Environmental stimuli are powerful mediators of craving and relapse in substance‐abuse
disorders. This review examined how animal models have been used to investigate the …
disorders. This review examined how animal models have been used to investigate the …
Fentanyl vapor self-administration model in mice to study opioid addiction
Intravenous drug self-administration is considered the “gold standard” model to investigate
the neurobiology of drug addiction in rodents. However, its use in mice is limited by frequent …
the neurobiology of drug addiction in rodents. However, its use in mice is limited by frequent …
A classically conditioned cocaine cue acquires greater control over motivated behavior in rats prone to attribute incentive salience to a food cue
LM Yager, TE Robinson - Psychopharmacology, 2013 - Springer
Rationale Cues associated with rewards bias attention towards them and can motivate drug-
seeking and drug-taking behavior. There is, however, considerable individual variation in …
seeking and drug-taking behavior. There is, however, considerable individual variation in …
Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence
M Bortolato, JC Shih - International review of neurobiology, 2011 - Elsevier
Monoamine oxidase (MAO) isoenzymes A and B are mitochondrial-bound proteins,
catalyzing the oxidative deamination of monoamine neurotransmitters as well as xenobiotic …
catalyzing the oxidative deamination of monoamine neurotransmitters as well as xenobiotic …
From prediction to action: dissociable roles of ventral tegmental area and substantia nigra dopamine neurons in instrumental reinforcement
Reward seeking requires the coordination of motor programs to achieve goals. Midbrain
dopamine neurons are critical for reinforcement, and their activation is sufficient for learning …
dopamine neurons are critical for reinforcement, and their activation is sufficient for learning …
Alpha7 nicotinic acetylcholine receptors modulate motivation to self-administer nicotine: implications for smoking and schizophrenia
DH Brunzell, JM McIntosh - Neuropsychopharmacology, 2012 - nature.com
Individuals diagnosed with schizophrenia have an exceptionally high risk for tobacco
dependence. Postmortem studies show that these individuals have significant reductions in …
dependence. Postmortem studies show that these individuals have significant reductions in …