Oxytocin and pain perception: from animal models to human research

S Boll, ACA De Minas, A Raftogianni, SC Herpertz… - Neuroscience, 2018 - Elsevier
An accumulating body of evidence suggests that the hypothalamic neuropeptide oxytocin
(OT) has a modulatory effect on pain processing. Particularly strong evidence comes from …

Oxytocin and brain activity in humans: a systematic review and coordinate-based meta-analysis of functional MRI studies

SA Grace, SL Rossell, M Heinrichs… - …, 2018 - Elsevier
Oxytocin (OXT) is a neuropeptide which has a critical role in human social behaviour and
cognition. Research investigating the role of OXT on functional brain changes in humans …

Increased thalamic glutamate/glutamine levels in migraineurs

A Bathel, L Schweizer, P Stude, B Glaubitz… - The journal of headache …, 2018 - Springer
Background Increased cortical excitability has been hypothesized to play a critical role in
various neurological disorders, such as restless legs syndrome, epilepsy and migraine …

Pain, parental involvement, and oxytocin in the neonatal intensive care unit

M Filippa, P Poisbeau, J Mairesse, MG Monaci… - Frontiers in …, 2019 - frontiersin.org
Preterm infants (PTI) typically experience many painful and stressful procedures or events
during their first weeks of life in a neonatal intensive care unit, and these can profoundly …

Re-examining the Mysterious Role of the Cerebellum in Pain

CN Li, KA Keay, LA Henderson… - Journal of …, 2024 - Soc Neuroscience
Pain is considered a multidimensional experience that embodies not merely sensation, but
also emotion and perception. As is appropriate for this complexity, pain is represented and …

Evaluating the efficacy of oxytocin for pain management: An updated systematic review and meta-analysis of randomized clinical trials and observational studies

AA Mekhael, JE Bent, JM Fawcett… - Canadian Journal of …, 2023 - Taylor & Francis
Background There is a need for novel analgesics with favorable risk to benefit profiles.
Oxytocin has recently gained attention for its potential analgesic properties. Aim The aim of …

[HTML][HTML] Effects of oxytocin on placebo and nocebo effects in a pain conditioning paradigm: a randomized controlled trial

A Skvortsova, DS Veldhuijzen, H van Middendorp… - The Journal of …, 2020 - Elsevier
Oxytocin has been shown to increase trust, decrease anxiety, and affect learning as has
been observed in conditioning paradigms. Trust, anxiety, and learning are important factors …

Intranasal oxytocin following uncontrollable stress blocks impairments in hippocampal plasticity and recognition memory in stressed rats

SH Park, YJ Kim, JC Park, JS Han… - International Journal of …, 2017 - academic.oup.com
Background Nasal pretreatment with the neuropeptide oxytocin has been reported to
prevent stress-induced impairments in hippocampal synaptic plasticity and spatial memory …

Oxytocin reduces romantic rejection-induced pain in online speed-dating as revealed by decreased frontal-midline theta oscillations

X Zhang, P Li, SCSA Otieno, H Li… - …, 2021 - Elsevier
Background Romantic rejection is an emotionally distressful experience profoundly affecting
life, possibly leading to mental illness or suicide. Oxytocin (OT) is a neuropeptide widely …

Enhancing placebo effects in somatic symptoms through oxytocin

A Skvortsova, DS Veldhuijzen… - Psychosomatic …, 2018 - journals.lww.com
Objective Placebo effects relieve various somatic symptoms, but it is unclear how they can
be enhanced to maximize positive treatment outcomes. Oxytocin administration may …