Vesicle-associated membrane protein (VAMP)-associated proteins (VAPs) are ubiquitous
ER-resident tail-anchored membrane proteins in eukaryotic cells. Their N-terminal major …

Herpes simplex virus 1 (HSV-1) replicates its genome and packages it into capsids within
the nucleus. HSV-1 has evolved a complex mechanism of nuclear egress whereby nascent …

ELYS is a nucleoporin that localizes to the nuclear side of the nuclear pore complex (NPC)
in interphase cells. In mitosis, it serves as an assembly platform that interacts with chromatin …

Nuclear egress of herpesvirus capsids across the intact nuclear envelope is an exceptional
vesicle-mediated nucleocytoplasmic translocation resulting in the delivery of herpesvirus …

DDX3X is a mammalian RNA helicase that regulates RNA metabolism, cancers, innate
immunity and several RNA viruses. We discovered that herpes simplex virus 1, a nuclear …

Vesicle-associated membrane protein–associated protein B (VAPB) is a tail-anchored
protein that is present at several contact sites of the endoplasmic reticulum (ER). We now …

Human herpesviruses are a ubiquitous family of viruses that infect individuals of all ages
and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad …

VAPB (Vesicle-Associated-membrane Protein-associated protein B) is a tail-anchored
membrane protein of the endoplasmic reticulum that can also be detected at the inner …

The envelope glycoprotein M (gM), a surface virion component conserved among
alphaherpesviruses, is a multiple-transmembrane domain-containing glycoprotein with a …

This study developed a system consisting of two rounds of screening cellular proteins
involved in the nuclear egress of herpes simplex virus 1 (HSV-1). Using this system, we first …