[HTML][HTML] VAP proteins–from organelle tethers to pathogenic host interactors and their role in neuronal disease
Vesicle-associated membrane protein (VAMP)-associated proteins (VAPs) are ubiquitous
ER-resident tail-anchored membrane proteins in eukaryotic cells. Their N-terminal major …
ER-resident tail-anchored membrane proteins in eukaryotic cells. Their N-terminal major …
[HTML][HTML] Host and viral factors involved in nuclear egress of herpes simplex virus 1
J Arii - Viruses, 2021 - mdpi.com
Herpes simplex virus 1 (HSV-1) replicates its genome and packages it into capsids within
the nucleus. HSV-1 has evolved a complex mechanism of nuclear egress whereby nascent …
the nucleus. HSV-1 has evolved a complex mechanism of nuclear egress whereby nascent …
Phosphorylation of ELYS promotes its interaction with VAPB at decondensing chromosomes during mitosis
ELYS is a nucleoporin that localizes to the nuclear side of the nuclear pore complex (NPC)
in interphase cells. In mitosis, it serves as an assembly platform that interacts with chromatin …
in interphase cells. In mitosis, it serves as an assembly platform that interacts with chromatin …
[HTML][HTML] The Knowns and unknowns of Herpesvirus nuclear egress
BG Klupp, TC Mettenleiter - Annual Review of Virology, 2023 - annualreviews.org
Nuclear egress of herpesvirus capsids across the intact nuclear envelope is an exceptional
vesicle-mediated nucleocytoplasmic translocation resulting in the delivery of herpesvirus …
vesicle-mediated nucleocytoplasmic translocation resulting in the delivery of herpesvirus …
[HTML][HTML] RNA helicase DDX3X modulates herpes simplex virus 1 nuclear egress
B Khadivjam, É Bonneil, P Thibault, R Lippé - Communications Biology, 2023 - nature.com
DDX3X is a mammalian RNA helicase that regulates RNA metabolism, cancers, innate
immunity and several RNA viruses. We discovered that herpes simplex virus 1, a nuclear …
immunity and several RNA viruses. We discovered that herpes simplex virus 1, a nuclear …
[HTML][HTML] Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane
Vesicle-associated membrane protein–associated protein B (VAPB) is a tail-anchored
protein that is present at several contact sites of the endoplasmic reticulum (ER). We now …
protein that is present at several contact sites of the endoplasmic reticulum (ER). We now …
[HTML][HTML] Modulation of endosome function, vesicle trafficking and autophagy by human herpesviruses
EI Tognarelli, A Reyes, N Corrales, LJ Carreño… - Cells, 2021 - mdpi.com
Human herpesviruses are a ubiquitous family of viruses that infect individuals of all ages
and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad …
and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad …
[HTML][HTML] Sequestosome 1 is part of the interaction network of VAPB
VAPB (Vesicle-Associated-membrane Protein-associated protein B) is a tail-anchored
membrane protein of the endoplasmic reticulum that can also be detected at the inner …
membrane protein of the endoplasmic reticulum that can also be detected at the inner …
[HTML][HTML] The Roles of envelope glycoprotein M in the life cycle of some alphaherpesviruses
C Li, M Wang, A Cheng, R Jia, Q Yang, Y Wu… - Frontiers in …, 2021 - frontiersin.org
The envelope glycoprotein M (gM), a surface virion component conserved among
alphaherpesviruses, is a multiple-transmembrane domain-containing glycoprotein with a …
alphaherpesviruses, is a multiple-transmembrane domain-containing glycoprotein with a …
Role of the orphan transporter SLC35E1 in the nuclear egress of herpes simplex virus 1
F Maeda, A Kato, K Takeshima, M Shibazaki… - Journal of …, 2022 - Am Soc Microbiol
This study developed a system consisting of two rounds of screening cellular proteins
involved in the nuclear egress of herpes simplex virus 1 (HSV-1). Using this system, we first …
involved in the nuclear egress of herpes simplex virus 1 (HSV-1). Using this system, we first …