HERV envelope proteins: physiological role and pathogenic potential in cancer and autoimmunity
N Grandi, E Tramontano - Frontiers in microbiology, 2018 - frontiersin.org
Human endogenous retroviruses (HERVs) are relics of ancient infections accounting for
about the 8% of our genome. Despite their persistence in human DNA led to the …
about the 8% of our genome. Despite their persistence in human DNA led to the …
Human endogenous retrovirus K (HML-2) in health and disease
B Xue, LA Sechi, DJ Kelvin - Frontiers in microbiology, 2020 - frontiersin.org
Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections
in the evolution of primates and account for about 8% of the human genome. They were …
in the evolution of primates and account for about 8% of the human genome. They were …
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …
Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
Tumour cells release an abundance of microvesicles containing a selected set of proteins
and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the …
and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the …
Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses
RP Subramanian, JH Wildschutte, C Russo, JM Coffin - Retrovirology, 2011 - Springer
Background Integration of retroviral DNA into a germ cell may lead to a provirus that is
transmitted vertically to that host's offspring as an endogenous retrovirus (ERV). In humans …
transmitted vertically to that host's offspring as an endogenous retrovirus (ERV). In humans …
Transposable element regulation and expression in cancer
EE Grundy, N Diab, KB Chiappinelli - The FEBS journal, 2022 - Wiley Online Library
Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …
Expression of these elements is tightly regulated during normal development. TEs may be …
Towards targeting Transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
A brief history of the status of transposable elements: from junk DNA to major players in evolution
C Biémont - Genetics, 2010 - academic.oup.com
The idea that some genetic factors are able to move around chromosomes emerged more
than 60 years ago when Barbara McClintock first suggested that such elements existed and …
than 60 years ago when Barbara McClintock first suggested that such elements existed and …
HERV-K (HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease
O Hohn, K Hanke, N Bannert - Frontiers in oncology, 2013 - frontiersin.org
Retroviruses that have the ability to infect germ line cells can become an integral and
inherited part of the host genome. About 8% of the human chromosomal DNA consists of …
inherited part of the host genome. About 8% of the human chromosomal DNA consists of …
Response of transposable elements to environmental stressors
IR Miousse, MCG Chalbot, A Lumen… - … Research/Reviews in …, 2015 - Elsevier
Transposable elements (TEs) comprise a group of repetitive sequences that bring positive,
negative, as well as neutral effects to the host organism. Earlier considered as “junk DNA,” …
negative, as well as neutral effects to the host organism. Earlier considered as “junk DNA,” …