Synthesis and Biological Studies of Benzo[b]furan Derivatives: A Review from 2011 to 2022

L Arce-Ramos, JC Castillo, D Becerra - Pharmaceuticals, 2023 - mdpi.com
The importance of the benzo [b] furan motif becomes evident in the remarkable results of
numerous biological investigations, establishing its potential as a robust therapeutic option …

Identification of pyrrolo [3′, 4': 3, 4] cyclohepta [1, 2-d][1, 2] oxazoles as promising new candidates for the treatment of lymphomas

M Barreca, V Spanò, R Rocca, R Bivacqua… - European journal of …, 2023 - Elsevier
Unsatisfactory outcomes for relapsed/refractory lymphoma patients prompt continuing efforts
to develop new therapeutic strategies. Our previous studies on pyrrole-based anti …

Current advances of tubulin inhibitors in nanoparticle drug delivery and vascular disruption/angiogenesis

S Banerjee, DJ Hwang, W Li, DD Miller - Molecules, 2016 - mdpi.com
Extensive research over the last decade has resulted in a number of highly potent tubulin
polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or …

Blocking blood flow to solid tumors by destabilizing tubulin: an approach to targeting tumor growth

MJ Pérez-Pérez, EM Priego, O Bueno… - Journal of medicinal …, 2016 - ACS Publications
The unique characteristics of the tumor vasculature offer the possibility to selectively target
tumor growth and vascularization using tubulin-destabilizing agents. Evidence accumulated …

[HTML][HTML] Novel pyrazolo [3, 4-d] pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action

Z Ruzi, K Bozorov, L Nie, J Zhao, HA Aisa - Biomedicine & …, 2022 - Elsevier
Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition,
and mechanisms of action - ScienceDirect Skip to main contentSkip to article Elsevier logo …

Versatile Electrochemical Synthesis of Selenylbenzo[b]Furan Derivatives Through the Cyclization of 2-Alkynylphenols

CV Doerner, MR Scheide, CR Nicoleti… - Frontiers in …, 2022 - frontiersin.org
We report an electrochemical oxidative intramolecular cyclization reaction between 2-
alkynylphenol derivatives and different diselenides species to generate a wide variety of …

Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the …

J Song, QL Gao, BW Wu, T Zhu, XX Cui, CJ Jin… - European Journal of …, 2020 - Elsevier
On the basis and continuation of our previous studies on anti-tubulin and anti-gastric cancer
agents, novel tertiary amide derivatives incorporating benzothiazole moiety were …

Molecular diversity of trimethoxyphenyl-1, 2, 3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors

DJ Fu, P Li, BW Wu, XX Cui, CB Zhao… - European Journal of …, 2019 - Elsevier
Abstract Structurally diverse trimethoxyphenyl-1, 2, 3-triazole hybrids were designed,
synthesized and evaluated for their antiproliferative activity against three cancer cell lines …

Synthesis and biological evaluation of 1-(benzofuran-3-yl)-4-(3, 4, 5-trimethoxyphenyl)-1H-1, 2, 3-triazole derivatives as tubulin polymerization inhibitors

ZY Qi, SY Hao, HZ Tian, HL Bian, L Hui, SW Chen - Bioorganic Chemistry, 2020 - Elsevier
The key functions of microtubules and the mitotic spindle in cell division make them
attractive targets for cancer therapy. In this study, a series of 1-(benzofuran-3-yl)-4-(3, 4, 5 …

Inhibition of the FGF/FGFR system induces apoptosis in lung cancer cells via c-Myc downregulation and oxidative stress

A Giacomini, S Taranto, S Rezzola… - International journal of …, 2020 - mdpi.com
Lung cancer represents an extremely diffused neoplastic disorder with different
histological/molecular features. Among the different lung tumors, non-small-cell lung cancer …