Harmonizing the neurobiology and treatment of obsessive-compulsive disorder

WK Goodman, EA Storch… - American Journal of …, 2021 - Am Psychiatric Assoc
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …

Defining functional brain networks underlying obsessive–compulsive disorder (OCD) using treatment-induced neuroimaging changes: a systematic review of the …

KR Bijanki, YJ Pathak, RA Najera, EA Storch… - Journal of Neurology …, 2021 - jnnp.bmj.com
Approximately 2%–3% of the population suffers from obsessive–compulsive disorder (OCD).
Several brain regions have been implicated in the pathophysiology of OCD, but their various …

Error processing and inhibitory control in obsessive-compulsive disorder: a meta-analysis using statistical parametric maps

LJ Norman, SF Taylor, Y Liu, J Radua, Y Chye… - Biological …, 2019 - Elsevier
Background Error processing and inhibitory control enable the adjustment of behaviors to
meet task demands. Functional magnetic resonance imaging studies report brain activation …

Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results …

B Davidson, C Hamani, JS Rabin, M Goubran… - Molecular …, 2020 - nature.com
Obsessive compulsive disorder (OCD) and major depressive disorder (MDD) are common,
often refractory, neuropsychiatric conditions for which new treatment approaches are …

Diagnostic classification for human autism and obsessive-compulsive disorder based on machine learning from a primate genetic model

Y Zhan, J Wei, J Liang, X Xu, R He… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: Psychiatric disorders commonly comprise comorbid symptoms, such as autism
spectrum disorder (ASD), obsessive-compulsive disorder (OCD), and attention deficit …

Deep brain stimulation versus ablative surgery for treatment‐refractory obsessive‐compulsive disorder: A meta‐analysis

SB Hageman, G van Rooijen… - Acta Psychiatrica …, 2021 - Wiley Online Library
Objective Ablative surgery (ABL) and deep brain stimulation (DBS) are last‐resort treatment
options for patients suffering from treatment‐refractory obsessive‐compulsive disorder …

Temporal variability of regional intrinsic neural activity in drug‐naïve patients with obsessive–compulsive disorder

J Liu, X Bu, X Hu, H Li, L Cao, Y Gao… - Human Brain …, 2021 - Wiley Online Library
Obsessive–compulsive disorder (OCD) displays alterations in regional brain activity
represented by the amplitude of low‐frequency fluctuation (ALFF), but the time‐varying …

Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice

GL Davis, AR Minerva, A Lario, LD Simmler… - Nature …, 2021 - nature.com
Abstract Obsessive-Compulsive Disorder (OCD), characterized by intrusive thoughts
(obsessions) and repetitive behaviors (compulsions), is associated with dysfunction in fronto …

Effectiveness and safety of neuroablation for severe and treatment-resistant obsessive–compulsive disorder: a systematic review and meta-analysis

Y Lai, T Wang, C Zhang, G Lin, V Voon, J Chang… - Journal of Psychiatry and …, 2020 - jpn.ca
Background: Several neuroablative procedures are available for severe and treatment-
resistant obsessive–compulsive disorder (OCD), but limited knowledge about their relative …

Mechanisms underlying capsulotomy for refractory obsessive-compulsive disorder: neural correlates of negative affect processing overlap with deep brain stimulation …

H Cui, Y Zhang, Y Zhao, Y Zhao, Q Ding, R Chen… - Molecular …, 2023 - nature.com
Ablative procedures such as anterior capsulotomy are potentially effective in refractory
obsessive-compulsive disorder (OCD). Converging evidence suggests the ventral internal …