Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Intercellular communication refers to the different ways through which cells communicate
with each other and transfer a variety of messages. These communication methods involve a …

Down syndrome (DS) is a genetic disorder driven by the triplication of chromosome 21 (T21)
and characterized by a wide range of neurodevelopmental and physical disabilities …

Increased life expectancies have significantly increased the number of individuals suffering
from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and …

Cellular senescence, first observed and defined through cell culture studies, is a cell fate
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …

Senescent cells trigger their own immune-mediated destruction, termed senescence
surveillance. This is dependent on the inflammatory senescence-associated secretory …

Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene
activation that can be transmitted to neighboring cells through secreted factors of the …

Oncogene-induced senescence (OIS) is a powerful intrinsic tumor-suppressive mechanism,
arresting cell cycle progression upon oncogene-activating genomic alterations. The …

Background Cellular senescence is a permanent state of replicative arrest defined by a
specific pattern of gene expression. The epigenome in senescent cells is sculptured in order …