Abstract 293 cell line (widely known as the Human Embryonic Kidney 293 cells) and its
derivatives were the most used cells after HeLa in cell biology studies and after CHO in …

Mistakes during cell division frequently generate changes in chromosome content,
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …

Single-cell RNA sequencing (RNA-seq) techniques can perform analysis of transcriptome at
the single-cell level and possess an unprecedented potential for exploring signatures …

Cancer is often regarded as a process of asexual evolution driven by genomic and genetic
instability. Mutation, selection and adaptation are by convention thought to occur primarily …

Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common …

Genetic instability is invoked in explaining the cell phenotype changes that take place during
cancer progression. However, the coexistence of a vast diversity of distinct clones, most …

Results of various cancer genome sequencing projects have “unexpectedly” challenged the
framework of the current somatic gene mutation theory of cancer. The prevalence of diverse …

Transient and stable vector transfections have played important roles in illustrating the
function of specific genes/proteins. The general assumption is that such a platform could …

Human tumors result from an evolutionary process operating on somatic cells within tissues,
whereby natural selection operates on the phenotypic variability generated by the …