A novel mechanism for regulating dopamine activity in subcortical sites and its possible
relevance to schizophrenia is proposed. This hypothesis is based on the regulation of …

The discovery that the brain contains neurons utilizing dopamine (DA) as their transmitter
has led to studies of the behavioral function of these neurons. Changes in overall level of …

This review summarizes the anatomical and functional organization of the frontal cortex of
the rat in comparison to primates. Lesions of the primary motor or of the prefrontal cortex of …

The prefrontal cortex (PFC) has long been known to be involved in the mediation of complex
behavioral responses. Considerable research efforts are directed towards refining the …

A widespread distribution of dopamine D 1 receptors in the neocortex is well recognized.
However, the presence of dopamine D 2 receptors in this structure has only recently been …

The benzamide derivative amisulpride shows a unique therapeutic profile being
antipsychotic, at high doses, and disinhibitory, at low doses, while giving rise to only a low …

Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

This chapter focuses on the transfer of information to the latter motor systems which range
from relatively simple circuits, such as the corticospinal projection from the motor cortex …

Publisher Summary The dopamine (DA) innervation of the prefrontal cortex (PFC) differs
from other mesotelencephalic DA terminal field regions in that it responds in a quantitatively …

The current information on the pharmacology and function of the DA innervation to the
prefrontal cortex is a synthesis of data from several initially distinct areas of research. Some …