Hypertension is the leading risk factor for heart disease and stroke, and is estimated to
cause 9.4 million deaths globally every year. The pathogenesis of hypertension is complex …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential
for the study of human cardiac disorders. However, their physiological immaturity severely …

Background: Dietary intake of fruit and vegetables is associated with lower incidence of
hypertension, but the mechanisms involved have not been elucidated. Here, we evaluated …

Highly ordered organisation of striated muscle is the prerequisite for the fast and
unidirectional development of force and motion during heart and skeletal muscle …

The development and progression of cardiovascular disease (CVD) can mainly be attributed
to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces …

The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play
important roles during skeletal muscle atrophy. Since then, numerous studies have been …

Titin has long been recognized as a mechanical protein in muscle cells that has a main
function as a molecular spring in the contractile units, the sarcomeres. Recent work suggests …

Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …

Skeletal muscles, being one of the most abundant tissues in the body, are involved in many
vital processes, such as locomotion, posture maintenance, respiration, glucose …