Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …

Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis
and high mortality rates. Conventional treatment strategies, such as surgery, chemotherapy …

Exposure to genotoxic stress promotes cell cycle arrest and DNA repair or apoptosis. These
“life” or “death” cell fate decisions often rely on the activity of the tumor suppressor gene p53 …

Abstract Islet-1 (ISL1) belongs to the LIM homeodomain transcription factor family, which is
specifically expressed in certain tissue types only. Previously, we reported that ISL1 is …

Cells have evolved mechanisms that allow them to respond to DNA damage to preserve
genomic integrity and maintain tissue homeostasis. These responses include the activation …

Adavosertib (also known as AZD1775 or MK1775) is a small-molecule inhibitor of the
protein kinase Wee1, with single-agent activity in multiple solid tumors, including sarcoma …

Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus belonging to
the genus Avibirnavirus in the family Birnaviridae. It can cause serious failure of vaccination …

Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate
the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell …

The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-
cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the …

Heart disease is associated with the accumulation of resident cardiac fibroblasts (CFs) that
secrete extracellular matrix (ECM), leading to the development of pathological fibrosis and …