Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …

Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

Axonal degeneration and neuronal cell death are fundamental processes in development
and contribute to the pathology of neurological disease in adults. Both processes are …

Medulloblastoma is the most common malignant paediatric brain tumour, representing 20%
of all paediatric intercranial tumours. Current aggressive treatment protocols and the use of …

Long noncoding RNAs (lncRNAs) play essential roles in the development and progression
of many cancers. However, the contributions of lncRNAs to medulloblastoma (MB) remain …

Cancer cells often express differentiation programs unrelated to their tissue of origin,
although the contribution of these aberrant phenotypes to malignancy is poorly understood …

Immunoglobulin light chain (AL) amyloidosis is an incurable hematologic disorder typically
characterized by the production of amyloidogenic light chains by clonal plasma cells. These …

Alterations in genes that regulate brain size may contribute to both microcephaly and brain
tumor formation. Here, we report that Aspm, a gene that is mutated in familial microcephaly …